Clinical Investigation

Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes

Obesity / Fertility / Infertility / Medicine / In Situ Hybridization / Signal Transduction / Glucose / Blood Glucose / Insulin / Diabetes mellitus / Mice / Hypothalamus / Female / Animals / Clinical / Body Composition / Male / Polymerase Chain Reaction / Peptides / Male Infertility / Proteins / Neurons / Phenotype / Genotype / Rats / Homeostasis / Neuropeptide Y / Time Factors / Body Weight / Protein isoforms / Female Infertility / Clinical Investigation / Gene Expression Regulation / Signal Transduction / Glucose / Blood Glucose / Insulin / Diabetes mellitus / Mice / Hypothalamus / Female / Animals / Clinical / Body Composition / Male / Polymerase Chain Reaction / Peptides / Male Infertility / Proteins / Neurons / Phenotype / Genotype / Rats / Homeostasis / Neuropeptide Y / Time Factors / Body Weight / Protein isoforms / Female Infertility / Clinical Investigation / Gene Expression Regulation

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Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes

Obesity / Fertility / Infertility / Medicine / In Situ Hybridization / Signal Transduction / Glucose / Blood Glucose / Insulin / Diabetes mellitus / Mice / Hypothalamus / Female / Animals / Clinical / Body Composition / Male / Polymerase Chain Reaction / Peptides / Male Infertility / Proteins / Neurons / Phenotype / Genotype / Rats / Homeostasis / Neuropeptide Y / Time Factors / Body Weight / Protein isoforms / Female Infertility / Clinical Investigation / Gene Expression Regulation / Signal Transduction / Glucose / Blood Glucose / Insulin / Diabetes mellitus / Mice / Hypothalamus / Female / Animals / Clinical / Body Composition / Male / Polymerase Chain Reaction / Peptides / Male Infertility / Proteins / Neurons / Phenotype / Genotype / Rats / Homeostasis / Neuropeptide Y / Time Factors / Body Weight / Protein isoforms / Female Infertility / Clinical Investigation / Gene Expression Regulation

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Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function

Prostate Cancer / Cell Differentiation / Humans / Transient receptor potential channels / Clinical / Male / Endoplasmic Reticulum / Alternative splicing / Prostate / Subcellular Localization / Epithelial cells / Alternative Splicing / Protein isoforms / Base Sequence / Subcellular Fractions / Clinical Investigation / Plasma Membrane / Cell Membrane / Male / Endoplasmic Reticulum / Alternative splicing / Prostate / Subcellular Localization / Epithelial cells / Alternative Splicing / Protein isoforms / Base Sequence / Subcellular Fractions / Clinical Investigation / Plasma Membrane / Cell Membrane

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Disease expression and molecular genotype in congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Humans / Mutation / Clinical / Pedigree / Phenotype / Congenital Adrenal Hyperplasia / Base Sequence / Clinical Investigation / Congenital Adrenal Hyperplasia / Base Sequence / Clinical Investigation

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Retinoic acid prevents experimental Cushing syndrome

Transcription Factors / Humans / Mice / Animals / Clinical / Retinoic Acid / Adrenocorticotropic Hormone / Tretinoin / Clinical Investigation / DNA binding proteins / Neuroendocrine Tumors / Cushing Syndrome / Pituitary Neoplasms / Retinoic Acid / Adrenocorticotropic Hormone / Tretinoin / Clinical Investigation / DNA binding proteins / Neuroendocrine Tumors / Cushing Syndrome / Pituitary Neoplasms

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P2Y6 receptor mediates colonic NaCl secretion via differential activation of cAMP-mediated transport

Immunohistochemistry / Xenopus / Video microscopy / cyclic AMP / Animals / Molecular cloning / Rats / Colon / Oocytes / Clinical Investigation / Sodium Chloride / Adenosine Triphosphate / Molecular cloning / Rats / Colon / Oocytes / Clinical Investigation / Sodium Chloride / Adenosine Triphosphate

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Fatty acid amide hydrolase deficiency limits early pregnancy events

Pregnancy / Mice / Female / Animals / Clinical / Endocannabinoids / Clinical Investigation / Endocannabinoids / Clinical Investigation

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Arterial and renal consequences of partial genetic deficiency in tissue kallikrein activity in humans

Genetics / Diet / Humans / Kidney / Mice / Aldosterone / Animals / Clinical / Male / Potassium / Phenotype / Mechanical Stress / Adult / Sodium / Vasodilation / Clinical Investigation / Cross-Over Studies / Atrial Natriuretic Factor / Brachial artery / Aldosterone / Animals / Clinical / Male / Potassium / Phenotype / Mechanical Stress / Adult / Sodium / Vasodilation / Clinical Investigation / Cross-Over Studies / Atrial Natriuretic Factor / Brachial artery

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Arterial and renal consequences of partial genetic deficiency in tissue kallikrein activity in humans

Genetics / Diet / Humans / Kidney / Mice / Aldosterone / Animals / Clinical / Male / Potassium / Phenotype / Mechanical Stress / Adult / Sodium / Vasodilation / Clinical Investigation / Cross-Over Studies / Atrial Natriuretic Factor / Brachial artery / Aldosterone / Animals / Clinical / Male / Potassium / Phenotype / Mechanical Stress / Adult / Sodium / Vasodilation / Clinical Investigation / Cross-Over Studies / Atrial Natriuretic Factor / Brachial artery

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PSD-95 expression controls l-DOPA dyskinesia through dopamine D1 receptor trafficking

Membrane Proteins / Macaca / Humans / Animals / Male / Levodopa / Rats / SYNAPSES / Clinical Investigation / Protein Transport / Parkinson Disease / Levodopa / Rats / SYNAPSES / Clinical Investigation / Protein Transport / Parkinson Disease

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Angiotensin II attenuates renal cortical cyclooxygenase-2 expression

Mice / Renin Angiotensin Aldosterone System / Animals / Clinical / Male / Rats / Isoenzymes / Rabbits / Losartan / Angiotensin II / Clinical Investigation / Angiotensin Converting Enzyme Inhibitors / Captopril / Rats / Isoenzymes / Rabbits / Losartan / Angiotensin II / Clinical Investigation / Angiotensin Converting Enzyme Inhibitors / Captopril

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PSD-95 expression controls l-DOPA dyskinesia through dopamine D1 receptor trafficking

Membrane Proteins / Macaca / Humans / Animals / Male / Levodopa / Rats / SYNAPSES / Clinical Investigation / Protein Transport / Parkinson Disease / Levodopa / Rats / SYNAPSES / Clinical Investigation / Protein Transport / Parkinson Disease

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Increased NOS2 predicts poor survival in estrogen receptor–negative breast cancer patients

Survival Analysis / Humans / Nitric oxide / Female / Animals / Survival Rate / Prognosis / Clinical Investigation / Gene expression profiling / Interleukin / Survival Rate / Prognosis / Clinical Investigation / Gene expression profiling / Interleukin

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Nuclear DNA origin of mitochondrial complex I deficiency in fatal infantile lactic acidosis evidenced by transnuclear complementation of cultured fibroblasts

Electron Microscopy / DNA / Mitochondrial DNA / Humans / Clinical / Male / Infant / Electron Transport / nuclear DNA / Newborn Infant / Cell nucleus / Hybrid Solar Cells / Human Fibroblasts / Clinical Investigation / Male / Infant / Electron Transport / nuclear DNA / Newborn Infant / Cell nucleus / Hybrid Solar Cells / Human Fibroblasts / Clinical Investigation

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P2Y6 receptor mediates colonic NaCl secretion via differential activation of cAMP-mediated transport

Immunohistochemistry / Xenopus / Video microscopy / cyclic AMP / Animals / Molecular cloning / Rats / Colon / Oocytes / Clinical Investigation / Sodium Chloride / Adenosine Triphosphate / Molecular cloning / Rats / Colon / Oocytes / Clinical Investigation / Sodium Chloride / Adenosine Triphosphate

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Arterial and renal consequences of partial genetic deficiency in tissue kallikrein activity in humans

Genetics / Diet / Humans / Kidney / Mice / Aldosterone / Animals / Clinical / Male / Potassium / Phenotype / Adult / Sodium / Vasodilation / Clinical Investigation / Cross-Over Studies / Atrial Natriuretic Factor / Aldosterone / Animals / Clinical / Male / Potassium / Phenotype / Adult / Sodium / Vasodilation / Clinical Investigation / Cross-Over Studies / Atrial Natriuretic Factor

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